Hello, I am on my 2nd jar and I havent given up hope yet. His breath is definitely much better, but I don't see much improvement, if any on his plaque. He was a little boy I rescued off the street who was skin and bone. Im sure his lifestyle contributed a lot to his plaque build-up. Like I said, Im still hoping to see improvement!! Thank you, Kathy and Toby🐾❤️🐾