After just 1-2 weeks of use, my dogs bumps (fatty deposits) seem to start shrinking. Now, a month later, it seems like things have stopped, but I'm still hopeful this is part of the process. He coat is shinier. She does itch & bite at her nails, but I'm thinking this may take time to change or could be due to other issues. For now, I'm happy with what I'm seeing and will be patient that positive changes continue!