I followed the instructions and applied two patches half an hour before drinking, and it definitely worked. I wasn't flushed red as I typically would have. The only drawback is the very unpleasant smell of the patches, and the sticky residue left, which was painful to remove from the skin. I can deal with the sticky residue, but I wish something could be done to improve the smelliness. The smell was quite pungent and I hoped no one else was distracted by the smell. Will I use the patches again? ...