To be honest, I was rather skeptical that these detox patches really did anything. However, within a day of using the first patch, I started getting weird activities in my intestinal areas, in particular, some really significant amount of constipation. I've been told that whenever you release toxins out of your body, that you need to help flush it out with drinking more water. That seemed to help. The sheer fact that I had ANY reaction from a patch that seems to have no chemical reaction (but ...